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Laboratory Detection of Thalassemia P. F. Milner pp.267-269
Published Date 1979/3/1
DOI https://doi.org/10.11477/mf.1543201811
  • Abstract
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The thalassemias are a heterogeneous group of genetically determined disorders*1 of hemoglobin synthesis and can be divided into α-thalassemias and β-thalassemias. The genes for these disorders are carried as relatively harmless traits*2 which can be detected in the laboratory by a series of tests. As there are several variant genes in each group, heterozygotes for two slightly different genes occur, and interaction of these thalassemia genes with the hemoglobinopathies is quite common. Severe clinical disease usually only occurs in homozygotes, as in Cooley's anemia. The problem for the laboratory is to distinguish thalassemia trait*3 from other causes of microcytosis and hypochromia in an economical and efficient way. The various proposed schemes are discussed, and it is suggested that detection of these traits should be part of a comprehensive screening program for hemoglobinopathies and thalassemias.


Copyright © 1979, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1375 印刷版ISSN 0301-2611 医学書院

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