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Japanese

Systemic sclerosis Yasushi Kawaguchi 1 1Institute of Rheumatology, Tokyo Women's Medical University Keyword: 強皮症 , 線維化 , 血管内皮障害 pp.1156-1163
Published Date 2011/10/30
DOI https://doi.org/10.11477/mf.1542102797
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Systemic sclerosis is a connective tissue disease characterized by tissue fibrosis and endothelial injury. In the last decade, several treatments for fibrosis and endothelial damage have been recommended from Europe, USA, and Japan. Fibrosis is treated by immunosuppressants including cyclophosphamide, and endothelial damage is treated by several kinds of vasodilators. Those therapies are effective and safe. Especially, endothelin receptor antagonist and phosphodiesterase 5 inhibitor are efficacious for the treatment of pulmonary hypertension and digital ulcers.


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電子版ISSN 1882-1367 印刷版ISSN 0485-1420 医学書院

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