Gastrointestinal Involvement in Patients with Scleroderma/Systemic Sclerosis Shotaro Nakamura 1 , Shigeo Nakamura 1 , Takayuki Matsumoto 1 1Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University Keyword: 強皮症 , 全身性硬化症 , 逆流性食道炎 , 小腸X線像 , 二重造影法 pp.535-541
Published Date 2003/4/24
DOI https://doi.org/10.11477/mf.1403100911
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 The gastrointestinal manifestations in patients with scleroderma (systemic sclerosis) are characterized by dilation of the gastrointestinal tract and reduced peristalsis caused by muscle atrophy and proliferation of collagen fibers in the muscularis propria. Esophageal involvement is observed in 50-90 % of patients. It manifests itself with dilation of the esophagus, hiatal hernia, while reflux esophagitis. The stomach is rarely involved, but small bowel manifestations are found in as many as 50 % of patients. Radiographic features of small bowel involvement with scleroderma is characterized by dilation of the duodenum and jejunum with marked crowding of the valvulae conniventes, showing hide-bound appearance or coiled-spring appearance. Colonic involvement is seen in 10-50 % of patients. It presents diverticula, constipation, stercoral ulcerations, or loss of haustration. In addition, an association between scleroderma and primary biliary cirrhosis has been suggested.

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