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Schizophrenia through analysis of aberrant alternative pre-mRNA splicing Takayuki Manabe 1 , Akila Mayeda 1 1Division of Gene Expression Mechanism, Institute for Comprehensive Medical Science, Fujita Health University Keyword: 選択的スプライシング , スプライシング異常 , 統合失調症 pp.893-899
Published Date 2011/9/15
DOI https://doi.org/10.11477/mf.1542102728
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Alternative pre-mRNA splicing plays a key role in the regulation of gene expression in both neurons and glial cells, and malfunction or dysregulation of the splicing process actually causes developmental abnormalities, leading to the pathological development involved in the eventual diseases. Schizophrenia is a very common mental disorder but it reveals pathogenic complexity. Intriguingly, misregulation of alternative splicing of genes associated with neurodevelopment and neurotransmission has been detected in schizophrenia. In this review, we describe the aberrant splicing of specific genes that are potentially involved in the cause of schizophrenia. Finally, we discuss the possibility of the diagnosis and treatment of schizophrenia through detecting the characteristic aberrant splicing as the hallmark.


Copyright © 2011, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1367 印刷版ISSN 0485-1420 医学書院

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