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mRNA surveillance : the mechanism of elimination of aberrant mRNAs Akio Yamashita 1,2 1Department of Microbiology, Yokohama City University 2Advanced Medical Research Center, Yokohama City University Keyword: mRNA監視機構 , ナンセンスコドン依存性mRNA分解機構 , ノンストップ依存性mRNA分解機構 , 翻訳伸長阻害依存mRNA分解機構 , 遺伝性疾患 pp.885-891
Published Date 2011/9/15
DOI https://doi.org/10.11477/mf.1542102727
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Eukaryotes have a conserved RNA surveillance mechanism to help maintain correct gene expression. Nonsense-mediated mRNA decay (NMD) is an mRNA surveillance mechanism that detects and degrades mRNAs containing premature termination codons (PTCs) to eliminate potentially harmful C-terminally truncated proteins. If C-terminally truncated proteins retain some of their function and/or PTC-read through produces functional proteins, NMD suppression leads to the phenotypic rescue of certain PTC-related mutations. The mRNA lacking a translation termination codon is recognized by Nonstop mRNA decay (NSD) pathways which eliminate nonstop mRNA. If translation is aberrantly arrested, mRNA degrade through No-go decay (NGD) pathway. Along with other types of quality control of mRNA that occur during each step of mRNA biogenesis (transcription, splicing and transport) these mRNA surveillance mechanisms help to ensue the integrity of gene expression.


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電子版ISSN 1882-1367 印刷版ISSN 0485-1420 医学書院

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