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Japanese

Cancer stem cells Daisaku Yamada 1 , Syuuji Ishii 2 , Syogo Kobayashi 1 , Naonori Hatano 1 , Hidekazu Takahashi 1 , Naoaki Haraguchi 1 , Hiroshi Wada 1 , Shigeru Maruhashi 1 , Hidetoshi Eguchi 1 , Kunihiro Tanemura 1 , Hiroaki Nagano 1 , Yuichiro Doki 1 , Masaki Mori 1 1Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University 2Department of Cancer Frontier Science, Graduate School of Medicine, Osaka University Keyword: 癌幹細胞 , 固形癌 , 癌治療 pp.445-452
Published Date 2011/5/15
DOI https://doi.org/10.11477/mf.1542102615
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It has recently become known that cancer can arise from small cell populations that differ from other progenies. These populations have the ability not only to renew themselves, but also to give rise to diverse phenotypes through the process of differentiation, and result in the formation of heterogeneous tumors. Because of their similarity to somatic stem cells, these small cell populations have been termed cancer stem cells (CSCs). The involvement of CSCs has been demonstrated in many tumors, and it is suggested that they play a role in resistance to anticancer therapy. The study of CSCs is expected to improve the current therapies and lead to novel therapies for such cancers in the future.


Copyright © 2011, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1367 印刷版ISSN 0485-1420 医学書院

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