Rinsho Kensa Volume 54, Issue 5 (May 2010)

Detection and clinical significance of multidrug-resistant organisms:ESBL producing strains Tetsuro Muratani 1 1Department of Clinical Laboratory, Kyurin Corporation Keyword: ESBL , ESBL検出法 , CLSI pp.505-512
Published Date 2010/5/15
DOI https://doi.org/10.11477/mf.1542102293
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Since the first description of plasmid-mediated ESBL in 1983, ESBL-producing gram-negative organisms have posed a significant threat to hospitalized patients due to their hydrolyzing activity against expanded-spectrum cephalosporins, which are often employed in the treatment of hospital-acquired infections. Detection of ESBL producers provides clinicians with helpful information. Treatment of infections caused by ESBL-producers with penicillins, all cephalosporins or monobactams may result in treatment failure even when the causative organisms appear to be susceptible to these antimicrobial agents by routine susceptibility testing. Regarding patients colonized or infected with ESBL-producers, it is important to carry out contact precautions to avoid hospital transmission. These benefits warrant the detection in clinical laboratories of ESBL-producing organisms.

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54巻5号 (2010年5月)
電子版ISSN 1882-1367 印刷版ISSN 0485-1420 医学書院