Detection and clinical significance of multidrug-resistant organisms:community acquired methicillin-resistant Staphylococcus aureus Tetsuo Yamaguchi 1,2 , Tetsuya Matsumoto 1,2 1Department of Microbiology, Tokyo Medical University 2Infection Control Team, Tokyo Medical University Hospital Keyword: CA-MRSA , PVL , SCCmec pp.497-503
Published Date 2010/5/15
DOI https://doi.org/10.11477/mf.1542102292
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MRSA(methicillin-resistant Staphylococcus aureus)has been a major causative agent of nosocomial infection. However, recently MRSA has become increasingly isolated from community associated infections. Although most community acquired MRSA(CA-MRSA)disease has been infection of skin or soft tissue, CA-MRSA also cause highly invasive, rapidly progressive, life-threatening diseases such as necrotizing pneumonia, severe sepsis and necrotizing fasciitis. In the USA, CA-MRSA known as USA300 is increasing rapidly and is now the leading cause of community associated bacterial infection. Analysis using SCCmec typing, pulsed field gel electrophoresis(PFGE), multi locus sequence typing(MLST), spa typing, and toxin gene pattern analysis have been used for epidemiological studies. But, we have little information about CA-MRSA in Japan. CA-MRSA may spread more in our country, so we should take care to respond to this danger.

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