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The possibility of application to laboratory medicine:lipid transfer proteins and reverse cholesterol transport Kazuyoshi Yamauchi 1 1Department of Medicine, Molecular Clinical Pathology, Graduate School of Comprehensive Human Sciences, University of Tsukuba Keyword: 高比重リポ蛋白(HDL) , apolipoprotein A-Ⅰ(apoA-Ⅰ) , コレステロール逆転送経路(RCT) , アテローム硬化症 , 冠動脈疾患(CHD) pp.375-381
Published Date 2010/4/15
DOI https://doi.org/10.11477/mf.1542102271
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Many studies demonstrated that the incidences of coronary heart disease, accompanied by atherosclerotic vascular disease, are negatively correlated with serum high density lipoprotein(HDL)cholesterol levels;therefore, HDL plays a protective role against atherosclerosis in blood vessels. In particular, reverse cholesterol transport(RCT)is the most important pathway by which accumulated cholesterol is delivered from the peripheral tissues to the liver for excretion, thus preventing atherosclerosis. Lecithin cholesterol acyltransferase(LCAT), cholesterol ester transfer protein(CETP), and phospholipid transfer protein(PLTP)are the major lipid transfer protein(LTP). As well as HDL and apolipoprotein AI, these LTPs are the crucial constituents of RCT, and play the role as acceptor for this pathway. Because the functional abnormalities of these LTPs and its related abnormalities I the lipoprotein metabolism are considered to be lead to the progression of atherosclerosis lesions, understanding the actual function of these LTPs on the development of atherosclerosis can help clarify those pathophysiological mechanism of atherosclerosis, and provide new therapeutic approaches to atherosclerotic cardiovascular diseases. This review presents the state of knowledge on the properties, function, and clinical significance of these LTPs in the RCT pathway.


Copyright © 2010, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1367 印刷版ISSN 0485-1420 医学書院

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