鼻アレルギー患者における血清総IgE値の診断的価値に関する考察

Consideration on the Diagnostic Value of Total Serum IgE levels in Patients with Nasal Allergy

I．緒言

　くしゃみ発作，水様性鼻汁，鼻閉を主訴とする鼻アレルギー患者の診断で重要なことの一つに，それがアトピー性であるかどうかを決定することがある。RIST法やPRIST法の普及に伴いその目的を検討するために血清総IgE値を測定することがルーチン化しつつある。しかしその正常値は種々であり，診断的価値の置き方にも異論がある。そこで著者らは血清総IgE値の意味するところについて若干の検討を加えた。

The clinical and diagnostic value of total serum IgE in the nasal allergy group (69 patients) and asymptomatic group (100 subjects) was evaluated. The total serum IgE level was measured by RIST or PRIST, and the specific IgE's against house dust (H 1), a mite, Dermatophagoides pteronyssinus (DP), Anthoxanthum odoratum, a mugwort Artemisiaindica, Alternaria tenuis, cat and Japanese cedar were measured. The results were as follows.

1. RIST and PRIST showed a good correlation in IgE concentrations 100U/ml or more but a poor correlation in IgE concentrations of less than 100U/ml.

2. The total serum IgE level was 152.37± 165.07U/ml (mean ± S.E. ) for the asymptomatic group. This level tended to reach a peak of 0~50 U/ ml followed by gradual decline.

The nasal allergy group showed a higher level of 307.38 ± 274.16U/ml but did not show a normal distribution.

3. In the asymptomatic group, many subjects also showed positive RAST reactions.

4. The total serum IgE level correlated with the number of RAST positive allergens or the total RAST score.