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Cis-Platinum Ototoxicity Yumiko Ohnishi 1 1Department of Otolaryngology University of Tokyo pp.937-942
Published Date 1984/11/20
DOI https://doi.org/10.11477/mf.1492209870
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 In 15 patients receiving cis-platinum chemotherapy, ototoxicity of the drug was investigated.

 Six patients showed hearing loss and roaring tinnitus. The hearing loss appeared at the total dose levels above 200mg of cisplatinum, and started at 8,000Hz, then developed at 4,000Hz through 2,000Hz.

 Audiometric investigation (SISI test, Bekesy audiometry, electrocochleogram) suggest that the origin of the hearing loss was in the cochlea, especially loss of the outer hair cells.

 Vestibular toxicity, on the contrary, was observed only in one patient who had dizzy sensation, but showed no abnormal vestibular findings.


Copyright © 1984, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 印刷版ISSN 0386-9679 医学書院

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