側頭骨HiStiocytosis-Xの2症例

Two Cases of Histiocytosis X of the Temporal Bone

　I．はじめに

　1953年，Lichtenstein^1）がeosinophilic granuloma，Hand-Schuller-Christian氏病，Letterer-Siwc病の3疾患を一つの範疇に入るものとしてhistiocytosis-Xと総称して以来，この名称が一般的に用いられることが多くなってきている。

　最近われわれは，側頭骨原発と思われるhistiocytosis-Xの2症例を経験し，併発した皮膚病変の真皮内に原病巣と同様の組織球浸潤を認め，電顕的に病的組織球の細胞内にLangerhans顆粒（Birbeckの顆粒^2））を認めたので，若干の文献的考察を加え報告する。

　Two cases of histiocytosis X in the temporal bone of a 15-month-old and a 14-month-old children are described. Histological examination of the surgicalspecimen revealed typical histological features of eosinophilic granuloma. Biopsy specimens from cutaneous lesions in each patient were also examined under an electron microscope. Langerhans granules were found in abnormal histiocytes in thesubdermal lesions, which are regarded as specific for Langerhans cell of the normal epidermis.

　The patients were treated with steroid and yin-blastin sulfate resulting in improvement of the primary tumor and skin lesions.