無カタラーゼ血液症の1例

A Case of Acatalasemia

　I．はじめに

　カタラーゼ血液症は血液中にカタラーゼ酵素を欠如する遺伝性疾患で，昭和21年高原らによって発見報告された^4）。本症発見の動機は10歳の少女の上顎歯槽部の骨壊疽の手術後，過酸化水素（以下H₂O₂と記す）で清拭した際，気泡が発生せず黒褐色に変化したことから研究が広範にわたり進展した。

　筆者らも31歳の婦人の鼻内手術後，H₂O₂で清拭して偶然発見したもので，若干の検索を行ったのでその概要を報告する。

　A case of acatalasemia (discoverd by S. Takahara 1946) in a 32-year-old woman is reported. She complained of headache and swelling of the left orbital region with acute frontal sinusitis. During endnasal operation, the wound was washed with hydrogen peroxide, where upon blood of the wound became blackened.

　By spectrophotometric test, the patient's blood was mixed with hydrogen peroxide and examined. Hemolytic Streptococci and Pneumococci were cultured in blood agar plates which contained the patient's blood and the difference of hemolysis around the bacterial colonies was observed between the agar plates with the patients blood and those with normal blood.

　Review of 102 cases of acatalasemia appearing in the literature was made.