新局麻薬Epirocainの耳鼻科領域に於ける使用経験

　緒言

　耳鼻咽喉科領域においては，粘膜病変を取り扱う事が大部分であるので，局所麻酔剤を必要とする事が非常に多い。之等は表面塗布或いは局所注射として使用される。Cocainを始め従来使用された局麻薬は，勿論多くの優秀性を有しているが，その毒性や習慣性において，又局所刺激の点において，又価格の点において，すべての好条件を具備したものは殆んど無い現状である。

　一般に耳鼻咽喉科の診療に使用する局所的薬剤は，その効果が確実であるほかに，粘膜細胞に対して有害な作用がなく，又同時に線毛機能に永久的障碍を与えぬものを選択する必要がある。

Epirocain is a new local anesthetic produ-ced by Eizai pharmacentical Co. ltd. in Japan.

The authors investigated the anethetical ability of this compound fundamentally, then we applied it to,patients in clinical uses.

We chiefly observed the influences action of this drug on the ciliary movements of the pharyngo-palatinal membranes of frogs and that of the tracheas of rabbits, and compared this results with other local anaesthetics, for examples Lidocaine and Cocaine.

When we used Epirocain as a surface ane-sthetics or a local infiltration anesthetics in water solution of 4% and 2% respectively, which was the enough concentration to get a good local anesthetical effects, the ciliary movements were little disturved and more ovew they were reversible.

In clinical application, Epirocain showed excellent effect for alleviation of pain during oto-rhinolaryngological operations.

The authors could observe observed hardly any side reaction of this drug in all series of experiences.