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- 文献概要
緒言最近抗ヒスタミン製剤の発達普及に伴い単に,アレルギー性疾患のみならす,各種疾患に広く応用されている.わが耳鼻咽喉科領域に於ても,アレルギー性鼻炎を始め,各種急性鼻炎其の他に用いられ,優秀な効果を得たと数多く報告されている.然し之等は皆臨床例の報告である為,其の効果の判定には釈然とせぬ事多い.私達は之を実験的に検索しようとし,家兎に実験的に急性鼻炎を惹起させ,之が病理組織像に就いて,抗ヒスタミン剤使用時と比較検討してみた.
HASEGAWA AND FUJIMURA caused experime-ntally a state of acute rhinitis in rabbits to study effects of anti-histaminic drugs upon non-allergic affections. Two anti-histamines "Restamin" and "Anergen"Were used.
That these drugs relieved the state of edema and decreased the amount of discherge was shown by histological examnination of nasal mucous memb-ranes. In view of this fact the authors maintaain that the use of the drug is an effective means by which nasal obstruct ions and excessive nasal dis-charges in any acute rhinitis may be treated.
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