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Radiation-induced leiomyosarcoma of the dura mater:a case report Nobuya MURAKAMI 1,3 , Takato MORIOKA 1 , Shunji NISHIO 1 , Kouichiro MATSUKADO 1 , Takanori INAMURA 1 , Masashi FUKUI 1 , Shinji KOUNO 2 1Department of Neurosurgery, Neurological Institute, Faculty of Medicine, Kyushu University 2Department of Pathology, Faculty of Medicine, Kyushu University Keyword: radiation therapy , brain neoplasm , astrocytoma , leiomyosarcoma , dura mater pp.1049-1053
Published Date 1997/11/10
DOI https://doi.org/10.11477/mf.1436901488
  • Abstract
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A 31-year-old man underwent total resection for a fibrillary astrocytoma in the right frontal lobe followed by 6MV x-ray radiotherapy. The portal field size was a square of 8cm×7cm, and the total dose of irradiation was 50Gy, with single fractions of 2Gy. For the next 6.5 years there was no recurrence of the astrocytoma. At 38 years of age, the patient noticed a subcutaneous mass in the scar of the previous operation and de-veloped generalized convulsive seizures. MRI revealed a dural tumor within the previous radiation field, and the tumor was partially removed. Histologically, it was diagnosed as a leiomyosarcoma. This dural sarcoma satisfies the widely used criteria for definition of radia-tion-induced malignancies first described by Cahan et al. Both the clinical features and the possible histogene-sis of this secondary tumor are briefly discussed.


Copyright © 1997, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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