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・孤発脳動静脈奇形の血管壁内皮細胞においてKRAS遺伝子の変異が高率に認められることが発見され,これを標的とした薬物治療の可能性が提示されている.
・脳動静脈奇形の外科的治療では症例を1例1例詳細に検討し,安全な摘出術を施行することが重要である.
Recently, a KRAS mutation located in the endothelial cells of the nidus in arteriovenous malformations(AVMs)was reported. The findings indicate the possibility of medical therapy against cerebral AVMs; the blockade of RAS-MAPK signaling cascade may stabilize AVM nidus. As for surgical treatment for AVMs, achievement of low morbidity is the most important objective. To achieve this, assessment of blood flow, usage of non-stick bipolar forceps, and 3D simulation prior to operation are important. Assessment of individual cases for surgical treatment leads to low morbidity in surgeries.
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