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Molecular Diagnostic Approaches for Diffuse Gliomas Based on Updated WHO Classification and cIMPACT-NOW Proposals Kenta MASUI 1 , Takashi KOMORI 2 1Division of Pathological Neuroscience, Department of Pathology, Tokyo Women's Medical University School of Medicine 2Department of Laboratory Medicine and Pathology(Neuropathology), Tokyo Metropolitan Neurological Hospital Keyword: 2016 WHO分類 , cIMPACT-NOW , びまん性神経膠腫 , グリオーマ , 統合診断 , 人工知能 , 2016 WHO classification , diffuse gliomas , integrated diagnosis , artificial intelligence , AI pp.510-519
Published Date 2021/5/10
DOI https://doi.org/10.11477/mf.1436204423
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 The updated 2016 World Health Organization(WHO)classification of tumors of the central nervous system(CNS)has incorporated molecular parameters into the histopathological diagnosis of the tumor in the name of “integrated diagnosis.” It has enabled more prognostically precise diagnoses of brain tumor entities; however, its practical application has also raised concerns about whether genotypes predominate over phenotypes in tumor diagnostics. In response, cIMAPCT-NOW(the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy-“Not Official WHO”)was established to provide a forum for evaluating and recommending proposed changes to future CNS tumor classifications. cIMPACT has thus far published seven updates on the proposal and clarification of existing and new terms and entities. Herein, we highlight the current status of clinical application of the 2016 WHO classification and cIMPACT proposals, and the future endeavor to incorporate comprehensive genomic and epigenomic profiling of CNS tumors with the aid of artificial intelligence technology for better clinical decision-making to achieve the goal of precision medicine for each patient with brain tumors.


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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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