Neurological Surgery No Shinkei Geka Volume 45, Issue 11 (November 2017)

Effect of Platelet Concentrate Transfusion on Prognosis of Patients with Intracerebral Hemorrhage Treated with Anti-Platelet Agents Kazutaka SUGIMOTO 1 , Hideyuki ISHIHARA 1 , Mizuya SHINOYAMA 1 , Hirokazu SADAHIRO 1 , Michiyasu SUZUKI 1 1Department of Neurosurgery, Yamaguchi University Graduate School of Medicine Keyword: platelet concentrate transfusion , intracerebral hemorrhage , anti-platelet agent pp.965-970
Published Date 2017/11/10
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 BACKGROUND:A recent randomized control study(the PATCH trial)found no beneficial effect of platelet concentrate(PC)transfusion on the prognosis of patients with intracerebral hemorrhage(ICH)treated with anti-platelet agents(APAs). However, the trial excluded surgical cases. In this study, we examined the effect of PC on ICH, including patients who received surgical treatment.

 METHOD:A retrospective cohort analysis was performed in 23(11 males, 12 females)of 35 patients diagnosed with ICH and treated with APAs between January 2010 and December 2015 at the Department of Neurosurgery, Yamaguchi University Hospital. Twelve patients were excluded due to the use of anticoagulants or replenishment of coagulation factors.

 RESULTS:PC transfusion was administered in 12 cases(PC group)but not administered in 11(non-PC group). Conservative therapy at admission was used in 7 and 9 cases in the PC and non-PC groups, respectively, and none of these cases showed hematoma enlargement during conservative therapy. Surgical treatment was performed in 6 and 2 patients in the PC and non-PC groups, respectively, and hematoma enlargement occurred postoperatively in one patient in each group. Outcomes at 3 months after onset showed no significant difference between the groups(mRS 0-3:6 vs. 5 cases, p=0.34). Patients who received PC had no serious adverse events during hospitalization.

 CONCLUSION:In this study, surgery after PC transfusion was performed without any problems. There was no difference in prognosis between patients who did and did not receive PC. These results suggest that surgery can be performed safely after PC transfusion.

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Neurological Surgery 脳神経外科
45巻11号 (2017年11月)
電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院