Neurological Surgery No Shinkei Geka Volume 45, Issue 11 (November 2017)

Bilateral Pallidotomy for Tardive Dystonia:A Case Report Kotaro KOHARA 1 , Takaomi TAIRA 1 , Shiro HORISAWA 1 , Tomoko HANADA 1 , Takakazu KAWAMATA 1 1Department of Neurosurgery, Tokyo Women's Medical University Keyword: tardive dystonia , bilateral pallidotomy , globus pallidus internus , safety pp.971-976
Published Date 2017/11/10
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 Tardive dystonia is a movement disorder related to the use of dopamine-receptor-blocking drugs. Several reports have shown that deep brain stimulation of the globus pallidus internus(GPi-DBS)is effective in treating tardive dystonia. However, a few reports demonstrated the efficacy of ablation of the GPi(pallidotomy). We herein report a case of tardive dystonia successfully treated with bilateral pallidotomy. A 32-year-old man developed severe tardive dystonia 10 years after the chronic use of antipsychotic drugs. Withdrawal of the drugs and botulinum toxin injections were ineffective. The patient underwent bilateral pallidotomy for tardive dystonia because of rejection of the implanted DBS devices. Significant improvement was observed, with a 95% decrease in the Burke-Fahn-Marsden Dystonia Rating Scale(BFMDRS)movement score, and no severe adverse events occurred. Symptomatic relief persisted for nine months. Pallidotomy is a feasible and efficacious procedure for tardive dystonia treatment without the use of hardware implantations.

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Neurological Surgery 脳神経外科
45巻11号 (2017年11月)
電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院