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Effect of Trihexyphenidyl-HCI on Posttraumatic Prolonged Disturbance of Consciousness: Report of two cases Mitsunobu KAIJIMA 1 , Hiroshi FUKUDA 1 , Masayuki TOMABECHI 1 , Akira HODOZUKA 1 1Department of Neurosurgery, Megumino Hospital Keyword: Trihexyphenidyl , Head trauma , Akinetic mutism , Parkinsonism pp.467-471
Published Date 1989/5/10
DOI https://doi.org/10.11477/mf.1436202821
  • Abstract
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Cases involving two patients who presented post-traumatic prolonged disturbance of consciousness (PTPDC), namely akinetic mutism, and recovered from it after treatment with trihexyphenidyl were reported.

Case 1: A seventy-one-year-old farmer. Five months after head injury, when he was first admitted to us, he was stable with signs of oligokinesia, katatonic posture, speechlessness, rigid muscle tones and positive cog-wheel phenomenon. One week after administration of the drug, his speech and voluntary movement improved remarkably.

Two months after the treatment, he was able to walk, and was discharged from the hospital.


Copyright © 1989, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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