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Treatment of Brain Tumor with Phenobarbital and Continuous Infusion of ACNU into Internal Carotid Artery Katsuhiro YUMITORI 1 , Junko YAMASHITA 2 , Tetsuaki TERAURA 1 , Hajime HANDA 2 1Department of Neurosurgery, Kyoto City Hospital 2Department of Neurosurgery, Kyoto University Keyword: Brain tumor , ACNU , Continuous infusion , Phenobarbital pp.165-171
Published Date 1983/2/10
DOI https://doi.org/10.11477/mf.1436201632
  • Abstract
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ACNU is well known to be an effective chemotherapeu-tic agent for brain tumor. It also has a strong toxicity tobone marrow. Recently phenobarbital (PB) was reportedto reduce the toxicity of ACNU by induction of hepaticmicrosomal enzyme which is related to the metabolism ofACNU, and possible effect of PB to protect bone marrowsuppression was suggested. Indeed the toxicity to bonemarrow may be reduced by administration of PB, but tumor-cidal effect of ACNU also becomes poorer because PBinduces the lower concentration of ACNU in the cir-culation around the tumor as well as that of general cir-culation.


Copyright © 1983, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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