雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Usefulness of Quantitative 1H-MR Spectroscopy for the Differentiation between Radiation Necrosis and Recurrence of Anaplastic Oligodendroglioma Tomonori ISOBE 1 , Hiroyoshi AKUTSU 1 , Tetsuya YAMAMOTO 1 , Masanari SHIIGAI 1 , Tomohiko MASUMOTO 1 , Kei NAKAI 1 , Shingo TAKANO 1 , Izumi ANNO 2 , Akira MATSUMURA 1 1Graduate School of Human Comprehensive Sciences,University of Tsukuba 2Ibaraki Prefectural University of Health Sciences Keyword: MRS , quantification , metabolites , radiation necrosis , recurrence pp.485-490
Published Date 2011/5/10
DOI https://doi.org/10.11477/mf.1436101430
  • Abstract
  • Look Inside
  • Reference

 We report a case,in which quantitative 1H-MR spectroscopy (MRS) was useful for the differentiation between radiation necrosis and a recurrent tumor. The present case is a 44-year-old man who underwent the subtotal removal of a mass lesion in the left frontal lobe. The histological diagnosis was anaplastic oligodendroglioma (WHO grade Ⅲ). Postoperatively,a fractionated radiotherapy (total 64Gy) and chemotherapy were performed. MRI after the radiotherapy showed no contrast enhancing lesion. MRI,5 years after the radiotherapy,showed a growing enhancing lesion and a T1 hypointensity lesion without enhancement,both of which indicated a recurrent tumor. MR spectroscopy was performed for the differential diagnosis of these lesions. The spectrum was acquired by the point resolved spectroscopy (PRESS) method by TR/TE=2,000 ms/68 ms,136 ms,and 272 ms and evaluated with peak pattern and quantification value of metabolite. MRS of the enhancing lesion demonstrated a decrease of the Choline-containing compounds (Cho) concentration,disappearance of N-acetylaspartate (NAA),decrease of Creatine/ Phosphocreatine (t-Cr) and presence of Lipids (Lip) and Lactate (Lac),all of which are characteristic finding of a radiation necrosis. The histological diagnosis of this lesion showed evidence also of radiation necrosis. On the other hand,MRS of the T1 hypointensity lesion without enhancement showed,a marked high peak of the Cho concentration,which is characteristic for a recurrent tumor. The histological findings of this lesion showed a diffuse proliferation of recurrent tumor cells. Quantitative 1H-MRS is a useful tool for the differentiation between radiation necrosis and recurrent tumors.


Copyright © 2011, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

関連文献

もっと見る

文献を共有