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Japanese

A Case of Central Nervous System Lymphoma and Metastasized to Breast after Remission by Methotrexate Chemotherapy Masaru OHTA 1 , Iwao TAKESHITA 1 , Kenichi MATSUMOTO 3 , Shiro MATSUOKA 1 , Kimiaki Ikeda 2 1Department of Neurosurgery,Kyusyu Rosai Hospital 2Department of Internal Medicine,Kyushu Rosai Hospital 3Department of Neurosurgery,Graduate School of Medical Sciences,Kyushu University Keyword: central nervous system , malignant lymphoma , metastasis , breast pp.263-268
Published Date 2005/3/1
DOI https://doi.org/10.11477/mf.1436100046
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We report a case of primary central nervous system lymphoma (PCNSL) who responded well to initial systemic chemotherapy, but subsequently developed breast metastasis with local recurrence in the brain 27 months after complete remission. The 53-year-old female suddenly felt weakness in her left extremity. She was transferred to the emergency ward in our hospital. Neurological examination on admission showed disorientated state and mild hemiparesis. Brain MRI showed a well enhanced round lesion in the right basal ganglia with perifocal edema. A stereotactic biopsy of the tumor made a diagnosis of classic diffuse non-Hodgkin's B-cell type lymphoma. She received chemotherapy with a high-dose methotrexate under a condition of 20% of Karnofsky Performance Status (KPS). She enjoyed a useful life for about 5 years (KPS ; 60~70%). Both recurrent and metastatic lesions responded poorly to various aggressive multiagent regimens of chemotherapy. An intensive initial treatment for the primary lesion and closely monitoring of the whole body at regular intervals are necessary for ensuring a long useful life.


Copyright © 2005, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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