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Developing and degenerating Purkinje cells in man: an immunohistochemical study using spot 35 protein, a Purkinje cell-specific protein, as a marker. Eisaku OHAMA 1 , Shigeki TAKEDA 1 , Fusahiro IKUTA 1 , Tohru YAMAKUNI 2,3 , Yasuo TAKAHASHI 2 1Department of Pathology, Brain Research Institute, Niigata University 2Department of Neuropharmacology, Brain Research Institute, Niigata University 3Mitsubishi-Kasei Institute of Life Science pp.255-269
Published Date 1987/4/10
DOI https://doi.org/10.11477/mf.1431905881
  • Abstract
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 The spot 35 protein is a cerebellar Cabinding protein which had been shown immunohistochemically to be localized in the cell bodies, dendrites and axons of the Purkinje cells of adult rat. Using the antiserum against the protein, we studied the morphology of the developing and degenerating human Purkinje cells by the peroxidase-antiperoxidase method.

 We examined a total of 66 human brains.They included 19 fetuses (15 to 27 weeks of gestation), 11 infancies (3 days to 2 years old), 3 ultrasenile brains (over the age of 100) without neurological diseases, 7 brains of spinocerebellar degeneration (52 to 66 years old), 9 brains of degenerative type of progressive myoclonus epilepsy and normal adult brains. The fetal brains were obtained 1 to 3 hours after death following therapeutic or spontaneous abortions. All the other brains were obtained at autopsy 45 minutes to 22 hours after death. The brains were fixed with 10% formalin or 4% paraform aldehyde solutions and embedded in paraffin. Sagittal and parasagittal sections, 6 pm thick, were cut serially from cerebellar vermis and hemispheres including the dentate


Copyright © 1987, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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