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Huntington's chorea and positron emission tomography Kazuhiro Kodama 1 , Fumio Shishido 2 , Masao Yamanaka 3 , Akira Baba 4 , Seiichi Tamachi 5 , Toshiro Yamasaki 6 , Yukio Tateno 6 , Takashi Inoue 1 , Ichizo Satoh 1 1Department of Neuropsychiatry, School of Medicine, Chiba University 2Division of Radiology and Nuclear Medicine, Research Institute of Brain and Blood Vessels 3Nakamura Hospital 4Department of Neuropsychiatry, Asahi General Hospital 5Department of Neurosurgery, School of Medicine, Chiba University 6Division of Clinical Research, National Institute of Radiological Sciences pp.287-296
Published Date 1984/4/10
DOI https://doi.org/10.11477/mf.1431905592
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Abstract

The recent literatures concerning Huntington's chorea have shown remarkable advances in the study of the disease. These can be summarized as follows.

First, in autopsy studies, the brain typically shows widespread neuronal cell loss and glial proliferation, particularly in the caudate, putamen and cerebral cortices.

Biochemically, decrease of substances such as GABA, GAD, choline acetyl transferase, substance-P etc., and increase of dopamine, noradrenaline, somatostatin etc. have been revealed in the basal ganglia.

Radiologic studies with pneumoencephalography and CT scan have shown marked caudate atrophy.


Copyright © 1984, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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