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Hereditary hyperbilirubinemia: Gunn rat, an animal model of impaired cerebellar development Yoshio SAWASAKI 1 1Department of Biochemical Genetics, Medical Research Institute, Tokyo Medical and Dental University pp.992-1000
Published Date 1979/10/10
DOI https://doi.org/10.11477/mf.1431905110
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Abstract

 Bilirubin encephalopathy (kernicterus) induces neurological dysfunction and mental retardation. It is unclear why bilirubin is selectively toxic for the CNS, especially for certain nerve cells. To study such a neurotoxicity of bilirubin, the investigation in in vivo situation may be indispensable.

 Kernicterus is also observed in Gunn rat. This mutant strain of Wistar rat shows autosomal recessive hereditary hyperbilirubinemia due to the defect in hepatic UDP-glucuronyltransferase. Shortly after birth, Gunn rat develops permanent jaundice and exhibits various neurological signs.


Copyright © 1979, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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