Molecular mcchanism of sleep-wake regulation Yoshihiro URADE 1 1Department of Molecular Behavioral Biology, Osaka Bioscience Institute Keyword: プロスタグランジンD2 , アデノシン , 睡眠中枢 , 遺伝子操作マウス pp.883-890
Published Date 2000/12/10
DOI https://doi.org/10.11477/mf.1431901200
  • Abstract
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Prostaglandin (PG) D2is the most potent endogenous sleep-promoting substance, and its mechanism of action is the best characterized among the various sleep substances thus far reported. PGD synthase, the enzyme that produces PGD2, is dominantly localized in the arachnoid membrane in the brain of various mammals and is secreted into the cerebrospinal fluid (CSF) as beta-trace, a major CSF protein. PGD2 thus produced is secreted into the CSF and circulates within the brain as a neurohormone.

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