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Parkin gene and Parkin protein; a key to understand nigral degeneration. Nobutaka HATTORI 1 , Hideki SHIMURA 1 , Shinichiro KUBO 1 , Yoshikuni MIZUNO 1 1Department of Neurology, Juntendo University School of Medicine Keyword: パーキンソン病 , 家族性パーキンソニズム , 常染色体劣性遺伝形式若年性パーキンソニズム , パーキン遺伝子 , パーキン蛋白 pp.555-566
Published Date 2000/8/10
DOI https://doi.org/10.11477/mf.1431901170
  • Abstract
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In most patients with Parkinson's disease (PD), the contribution of genetic factors as well as environmental factors remains to be elucidated. But, it has become clear that genetic factors contribute to the pathogenesis of Parkinson's disease after identification of the distinct genetic loci for certain forms of familial Parkinson's disease and parkinsonism. The gene for an autosomal dominant familial form of Parkinson's disease was found to be caused by mutations of the alpha -synuclein gene, and we recently identified the novel large gene “parkin” responsible for an autosomal recessive form of familial parkinsonism (AR-JP).


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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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