Familial Parkinson's disease. Yoshikuni MIZUNO 1 , Zbigniew K. Wszolek 2 , Nobutaka HATRORI 1 1Department of Neurology, Juntendo University School of Medicine 2Department of Neurology, Mayo Ciinic Jacksonville Keyword: パーキンソン病 , Parkinson's disease , 家族性パーキンソン病 , Familial Parkinson's disease , 遺伝 , Genetics , シヌクレイン , α-synuclein , パーキン , parkin pp.539-554
Published Date 2000/8/10
DOI https://doi.org/10.11477/mf.1431901169
  • Abstract
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About 5 to 10% of Parkinson's disease are believed to be familial. Both autosomal dominant and autosomal recessive inheritance are known. Majority is autosomal dominant. There has been tremendous progress in the molecular pathology of familial Parkinson's disease in recent years. In this article, we review both clinical and genetic aspects of familial Parkinson's disease. The first type of familial Parkinson's disease in which the disease gene was identified was the autosomal dominant familial PD linked to the long arm of chromosome 4 (4g21-22).

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