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Genes responsible for Alzheimer's disease Masaki Ikeda 1 , Masaki Nishimura 1 , P. H. St George-Hyslop 1 1University of Toronto, Centre for Research in Neurodegenerative Diseases Keyword: 家族性アルツハイマー病 , プレセニリン , APP , アポリポプロテインE pp.872-878
Published Date 1997/12/10
DOI https://doi.org/10.11477/mf.1431901005
  • Abstract
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Alzheimer's disease (AD) is a common cause of dementia. The etiology of AD is complex. Several different genetic and non-genetic factors can cause the characteristic clinical and neuropathological hallmarks of AD.

To date, four genes responsible for Alzheimer's disease are known, namely APP, Apolipoprotein E, Presenilins (PS 1/PS 2). Mutations in the APP gene were found in only a small number of FAD families.


Copyright © 1997, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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