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Molecular genetics of migraine headaches Tetsuya Takahashi 1 1Department of Neurology, Brain Research Institute, Niigata University Keyword: 家族性片麻痺性片頭痛 , CACNA1A , ATP1A2 pp.707-713
Published Date 2004/10/10
DOI https://doi.org/10.11477/mf.1431100227
  • Abstract
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 Migraine is characterized by episodic throbbing headache, usually located on one side of the head. It is associated with genetic factors as well as environmental stress. In 1996, causative gene of familial hemiplegic migraine(FHM)was subsequently identified as the CACNA1A gene, encoding a P/Q-type calcium channel a1A subunit. Recently, ATP1A2 gene encoding the A1A2 Na/K-ATPase subunit has been reported to be causative for FHM. The CACNA1A gene is also causative for spinocerebellar ataxia type 6, moreover, FHM families having mutation in the CACNA1A gene exhibit a progressive cerebellar ataxia resembling spinocerebellar degeneration. The dysfunction of these channel permeability may lead migrainous attack or cerebellar degeneration.


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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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