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Molecular mechanisms of brain regionalization Tadashi Nomura 1 , Noriko Ohsumi 1 1Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research on Human Disease, Tohoku University Graduate School of Medicine Keyword: 領域化 , 区画化 , 細胞移動 , 進化 pp.35-43
Published Date 2005/2/10
DOI https://doi.org/10.11477/mf.1431100004
  • Abstract
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Regionalization is one of the fundamental processes in early stages of vertebrate brain development. In this process immature neuroepithelial cells acquire specific characters and establish specific territories named as compartments. In later stages, various types of neurons are born from specific brain regions and constitute complex neuronal circuits. Here we focus on the mechanisms of the regionalization in the developing brain, and introduce several responsible molecules for establishment of this process. We also discuss on the role of the regionalization in neuronal migrations and in axonal formations during brain development. Finally we argue causal relationship between brain regionalization and evolution of the vertebrate telencephalon.


Copyright © 2005, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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