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Immune-Mediated Cerebellar Ataxias Hiroshi Mitoma 1 1Department of Medical Education, Tokyo Medical University Keyword: 自己免疫性小脳性運動失調症 , グルテン失調症 , 傍腫瘍性小脳変性症 , 抗GAD抗体陽性小脳性運動失調症 , immune-mediated cerebellar ataxias , gluten ataxia , paraneoplastic cerebellar degeneration , anti-GAD ataxia pp.611-619
Published Date 2021/5/1
DOI https://doi.org/10.11477/mf.1416201805
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Abstract

Autoimmune mechanisms insult the cerebellum, resulting in the development of cerebellar ataxias (CAs). These immune-mediated cerebellar ataxias (IMCAs) include gluten ataxia, postinfectious cerebellitis, paraneoplastic cerebellar degeneration (PCD), antiglutamate decarboxylase 65 antibody-associated CA (anti-GAD ataxia), and primary autoimmune cerebellar ataxia (PACA). Cell-mediated mechanisms are assumed to be involved in PCD, whereas accumulating evidence shows that anti-GAD antibodies decrease the amount of GABA released which leads to functional synaptic deficits. The therapeutic benefits of immunotherapies vary depending on the etiology of the disease. Early intervention is recommended while the cerebellar reserve can be preserved.


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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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