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Paraneoplastic Disorders of the Central Nervous System Akio Kimura 1 1Department of Neurology, Gifu University Graduate School of Medicine Keyword: 液性免疫 , 抗神経抗体 , 細胞性免疫 , 傍腫瘍性神経症候群 , 免疫チェックポイント阻害薬 , humoral immunity , antineuronal antibody , cellular immunity , paraneoplastic neurologic syndrome , immune checkpoint inhibitor pp.620-630
Published Date 2021/5/1
DOI https://doi.org/10.11477/mf.1416201806
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Abstract

Paraneoplastic neurological syndromes (PNS) are neurological disorders that occur as indirect immune-mediated responses to malignancies. The increased number of patients with PNS correlates with the discovery of an increasing number of novel autoantibodies associated with PNS. The use of immune checkpoint inhibitors that have expanded the range of cancers strongly associated with PNS has likely increased the frequency of PNS diagnoses. This article presents an overview of the pathophysiology, diagnosis, therapy, and prognosis of PNS.


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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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