Autoantibodies Associated with Autoimmune-mediated Cerebellar Ataxia Hiroshi Mitoma 1 , Kazunori Nanri 2 1Department of Medical Education, Tokyo Medical University 2Department of Neurology, Tokyo Medical University Hachioji Medical Center Keyword: autoantibodies , paraneoplastic syndrome , anti-GAD antibody , gluten ataxia , Hashimoto encephalopathy , cerebellar ataxia pp.355-364
Published Date 2013/4/1
DOI https://doi.org/10.11477/mf.1416101460
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 Various autoantibodies are associated with autoimmune-mediated cerebellar ataxia. Anti-Yo, -Zic, -CARPVIII, -Tr, -Ri, -Hu, -Ma, -CRMP-5, -ANNA-3, -PCA-2, -VGCC, and -mGluR antibodies (Abs) are found in paraneoplastic cerebellar ataxia, whereas anti-GAD, -thyroid, and -gliadin Abs are found in non-paraneoplastic cerebellar ataxia. Most of these antibodies are not pathogenic but are diagnostic markers. However, anti-VGCC, anti-mGluR, and anti-GAD Abs have been shown to cause cerebellar ataxia, because administration of these Abs mimics cerebellar ataxia in vivo. Experiments using in vitro preparations show that anti-VGCC Ab depresses excitatory synaptic transmissions, and anti-GAD Ab suppresses inhibitory synaptic transmissions. Anti-mGluR Ab interferes with the induction of synaptic plasticity. These results suggest that pathogenic Abs elicit cerebellar synaptic dysfunction, and thereby cause ataxia in patients.

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