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Split Hand: characteristic neurological symptoms in ALS Kazumoto Shibuya 1 1Department of Neurology, Graduate School of Medicine, Chiba University Keyword: 解離性小手筋萎縮 , 筋萎縮性側索硬化症 , 脱力分布 , 興奮毒性 , split hand , amyotrophic lateral sclerosis , distribution of weakness , excitotoxicity pp.1145-1151
Published Date 2019/11/1
DOI https://doi.org/10.11477/mf.1416201425
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Abstract

‘Split hand’ is dissociated hand muscle atrophy, characterized by preferential atrophies in the thenar and first dorsal interosseous muscles, with relative sparing of the hypothenar muscle. This symptom has been recognized as specific to amyotrophic lateral sclerosis (ALS), and distinct pathomechanisms are assumed to underlie this phenomenon. Recently, characteristic distributions of weakness and symptoms in ALS have been reported. Here, we describe characteristic symptoms of ALS, including split hand, split-hand plus sign, split elbow, split leg, relative preservation of finger flexion. Moreover, through these phenomena, potent mechanisms of motor neuron death in ALS are considered. Revealing the underlying pathophysiology of these symptoms may lead to the development of therapies for ALS.


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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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