Cortical Motor Neuron Hyperexcitability and Motor Neuron Death in ALS: Dying Forward Hypothesis Kazumoto Shibuya 1 1Department of Neurology, Graduate School of Medicine, Chiba University Keyword: 筋萎縮性側索硬化症 , 神経興奮性 , 興奮毒性 , 病態進展 , 順行性細胞死仮説 , amyotrophic lateral sclerosis , neuronal excitability , excitotoxicity , pathogenetic progression , dying forward hypothesis pp.565-569
Published Date 2017/5/1
DOI https://doi.org/10.11477/mf.1416200783
  • Abstract
  • Look Inside
  • Reference


In the late 19th century, Charcot examined patients with amyotrophic lateral sclerosis (ALS) and concluded that the sclerosis in the lateral columns of the spinal cord induced the loss of neurons in the anterior horns. The reason for this remains unknown. In contrast, hyperexcitability of motor neurons is believed to be one of the pathogenetic factors for motor neuron death in ALS. In this article, I have reviewed the relationship between motor neuron hyperexcitability and motor neuron death and considered the mechanism of ALS pathogenesis.

Copyright © 2017, Igaku-Shoin Ltd. All rights reserved.


電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院