BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 70, Issue 7 (July 2018)

Mechanisms Associated with the Development of Traumatic Memories in Posttraumatic Stress Disorder Yuki Kobayashi 1 , Jun Shigemura 1 , Aihide Yoshino 1 1Department of Psychiatry, National Defense Medical College Keyword: 心的外傷後ストレス障害 , PTSD , トラウマ記憶 , 恐怖条件付け , 恐怖消去 , ストレス反応 , posttraumatic stress disorder , traumatic memory , fear conditioning , fear extinction , stress response pp.813-820
Published Date 2018/7/1
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Some individuals who experience psychologically traumatic events cannot process their experiences as regular memories, and these experiences develop into traumatic memories. In individuals with posttraumatic stress disorder (PTSD), fear conditioning occurs—these individuals subsequently respond to their direct traumatic experiences and to neutral stimuli. This conditioned response eventually leads to repeated re-experiencing. In this review, we discuss biological mechanisms associated with the development of traumatic memories. These mechanisms include neural networks connecting the amygdala, hippocampus, and ventromedial prefrontal cortex, as well as the hypothalamic-pituitary-adrenal axis of the endocrine system, and epigenetic changes.

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BRAIN and NERVE-神経研究の進歩
70巻7号 (2018年7月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院