BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 70, Issue 1 (January 2018)
Japanese

Immunopathogenesis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Takashi Yamamura 1 , Hirohiko Ono 1 , Wakiro Sato 1 1Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry Keyword: 筋痛性脳脊髄炎/慢性疲労症候群 , 炎症性サイトカイン , 自己免疫 , ナチュラルキラー細胞 , リツキシマブ , myalgic encephalomyelitis/chronic fatigue syndrome , ME/CFS , proinflammatory cytokine , autoimmune , natural killer cell , rituximab pp.35-40
Published Date 2018/1/1
DOI https://doi.org/10.11477/mf.1416200947
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Abstract

A recent study on the pathogenesis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) has revealed an elevation of inflammatory and anti-inflammatory cytokines in the sera and cerebrospinal fluids of the patients and presence of autoantibodies in subgroups of ME/CFS patients. Furthermore, investigator-initiated clinical trials have proved the efficacy of anti-CD20 antibody (rituximab), that eliminate B cells, in the treatment of ME/CFS. Based on these findings, we hypothesize that immune abnormalities, such as enhanced autoimmune responses, may play an essential role in the neuroinflammatory pathogenesis of ME/CFS.


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基本情報

18816096.70.1.jpg
BRAIN and NERVE-神経研究の進歩
70巻1号 (2018年1月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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