BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 70, Issue 1 (January 2018)

Neurologic Abnormalities in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Review Anthony L. Komaroff 1 , Ryosuke Takahashi 2 , Takashi Yamamura 3 , Masanori Sawamura 2 1Department of Medicine, Brigham & Women's Hospital, Harvard Medical School 2Departments of Neurology, Kyoto University Graduate School of Medicine 3Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry Keyword: 免疫活性化 , 炎症 , サイトカイン , 感染性因子 , エネルギー代謝異常 , 酸化ストレス , immune activation , inflammation , cytokine , infectious agent , abnormalities in energy metabolism , oxidative stress pp.41-54
Published Date 2018/1/1
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Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is an illness characterized by fatigue lasting for at least six months, post-exertional malaise, unrefreshing sleep, cognitive impairment and orthostatic intolerance. ME/CFS has been a controversial illness because it is defined exclusively by subjective complaints. However, recent studies of neuroimaging as well as analysis of blood markers, energy metabolism and mitochondrial function have revealed many objective biological abnormalities. Specifically, it is suspected that the symptoms of ME/CFS may be triggered by immune activation - either inside or outside the brain - through release of inflammatory cytokines. In this review, we summarize potentially important recent findings on ME/CFS, focusing on objective evidence.

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BRAIN and NERVE-神経研究の進歩
70巻1号 (2018年1月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院