Neuroinflammation in the Brain of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Yasuhito Nakatomi 1,2 , Hirohiko Kuratsune 2,3,4 , Yasuyoshi Watanabe 5,6,7 1Nakatomi Fatigue Care Clinic 2Osaka City University Fatigue Clinical Center 3Kansai University of Welfare Sciences, Faculty of Health Science 4Department of Metabolism, Endocrinology and Molecular Medicine, Faculty of Medicine, Osaka City University 5RIKEN Center for Life Science Technologies 6RIKEN Compass to Healthy Life Research Complex Program 7Osaka City University, Center for Health Science Innovation Keyword: 脳内神経炎症 , 筋痛性脳脊髄炎/慢性疲労症候群 , ポジトロンエミッション断層撮影 , PET , neuroinflammation , myalgic encephalomyelitis/chronic fatigue syndrome , ME/CFS , positron emission tomography pp.19-25
Published Date 2018/1/1
DOI https://doi.org/10.11477/mf.1416200945
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Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by chronic, profound, disabling, and unexplained fatigue; cognitive impairment; and chronic widespread pain. By using positron emission tomography, our study demonstrated neuroinflammation in the brain of patients with ME/CFS. Neuroinflammation was found to be widespread in the brain areas of the patients with ME/CFS and was associated with the severity of their neuropsychological symptoms. The ongoing research would lead to the establishment of objective diagnostic criteria and development of an appropriate therapy.

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