BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 70, Issue 1 (January 2018)

History of Researches on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Yasuyoshi Watanabe 1,2,3 , Hirohiko Kuratsune 4,5,6 1RIKEN Center for Life Science Technologies 2RIKEN Compass to Healthy Life Research Complex Program 3Osaka City University, Center for Health Science Innovation 4Kansai University of Welfare Sciences, Faculty of Health Welfare 5Department of Metabolism, Endocrinology and Molecular Medicine, Faculty of Medicine, Osaka City University 6Osaka University Hospital, Fatigue Clinical Center Keyword: 筋痛性脳脊髄炎/慢性疲労症候群 , ME/CFS , 研究史 , 診断 , 治療 , 神経炎症 , ミクログリア活性化 , PET検査 , myalgic encephalomyelitis/chronic fatigue syndrome , research history , diagnosis , treatment , neuroinflammation , microglial activation , positron emission tomography pp.5-9
Published Date 2018/1/1
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Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease characterized by chronic, profound, disabling, and unexplained fatigue. The first patient with ME/CFS in Japan was identified and described in 1990 by Prof. Teruo Kitani and Dr. Hirohiko Kuratsune of the Research Institute for Microbial Diseases, Osaka University. Since then, a variety of studies have been performed to determine the objective biomarkers of the disease. Although it is hypothesized that brain inflammation is involved in the pathophysiology of ME/CFS, there is to date no direct evidence of neuroinflammation in patients with ME/CFS. Our recent positron emission tomography study successfully demonstrated that microglial activation, which is linked to neuroinflammation, occurs in widespread brain areas in patients with ME/CFS, and is associated with the severity of the neuropsychological symptoms. Thus, evaluation of neuroinflammation in patients with ME/CFS may be essential for understanding the core pathophysiology of the disease, and for developing objective diagnostic criteria and effective medical treatments for ME/CFS. Here, we describe disease-related pathophysiological findings and topics, and discuss the history of the diagnostic and therapeutic attempts based on previous findings in Japan.

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BRAIN and NERVE-神経研究の進歩
70巻1号 (2018年1月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院