BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 69, Issue 9 (September 2017)

Translational Research on Neuropsychiatric Disorders: Focusing on Microglia Hypothesis Takahiro A. Kato 1,2 , Masahiro Ohgidani 1 , Shigenobu Kanba 1,2 1Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University 2Department of Neuropsychiatry, Kyushu University Hospital Keyword: ミクログリア , 誘導ミクログリア様細胞 , 統合失調症 , うつ病 , 那須・ハコラ病 , microglia , induced microglia-like cells (iMG) , schizophrenia , depression , Nasu-Hakola disease pp.1007-1015
Published Date 2017/9/1
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Microglia—immune cells in the brain—have recently been highlighted to understand the pathophysiology of psychiatric disorders such as schizophrenia, depression, and autism. In this review paper, we introduce the microglia hypothesis for psychiatric disorders. In addition, we introduce our novel translational research approach to psychiatric disorders using microglia-like (iMG) cells directly induced from human blood, these iMG cells can be produced from peripheral monocytes within two weeks using two cytokines: granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-34 (IL-34).

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BRAIN and NERVE-神経研究の進歩
69巻9号 (2017年9月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院