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Microglial Response to Brain Temperature and Neuronal Circuit Reorganization Junya Onodera 1 , Yuji Ikegaya 1,2,3 , Ryuta Koyama 1,2 1Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo 2Institute for AI and Beyond 3Center for Information and Neural Networks Keyword: ミクログリア , TRP , シナプス , 脳内温度 , microglia , synapse , brain temperature pp.133-142
Published Date 2022/2/1
DOI https://doi.org/10.11477/mf.1416201998
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Abstract

Brain tissue is vulnerable to temperature changes, which are known to affect the structure and function of neural circuits. Owing to their dynamic ramified processes, microglia, which serve as immune cells in the brain, are associated with surveillance of the brain environment and mediate synaptic pruning to reorganize neural circuits. In this section, we discuss the possible role of microglia as temperature sensors in the brain via thermosensitive transient receptor potential channels and their role in reorganization of neural circuits.


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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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