BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 69, Issue 9 (September 2017)
Japanese

Microglia in Brain Development Masaki Ueno 1 1Brain Research Institute, Niigata University Keyword: 脳発達 , ミクログリア , brain development , microglia pp.985-997
Published Date 2017/9/1
DOI https://doi.org/10.11477/mf.1416200858
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Abstract

Microglia, traditionally known as resident immune cells in the brain, have been recently identified as one of the important cell types engaging in the formation and maintenance of neural circuitry, especially during the development. In this review, I describe the diversity of microglial functions revealed in different phases of development, ranging from neurogenesis to circuit formation. In particular, microglia possess dual functions in supporting the survival of neuronal structures or neural cells themselves, and removing excess neural components. Understanding these processes and underlying molecular mechanisms will provide important insights into the regulation of neural circuitry development. It further implicates the involvement of microglial dysfunction in neurodevelopmental disorders.


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基本情報

18816096.69.9.jpg
BRAIN and NERVE-神経研究の進歩
69巻9号 (2017年9月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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