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内側側頭葉に位置する海馬体の機能は,スライス標本や成体動物を用いた研究が盛んに行われてきた。最近では,多チャンネル計測用電極の開発や機械工作技術の向上により,海馬の神経細胞群が機能的にも構造的にもさらに多様な性質を有することが示されている。本論では特に,海馬回路によるパターン情報処理,目的指向型行動の表象,正負の価値の表象,について近年の研究動向を述べる。
Abstract
The hippocampal formation located in the medial temporal lobe of the brain has been studied extensively for several decades, both in in vitro slice preparations and in vivo living animals. Recent advancements in large-scale recording techniques, such as multisite silicon probes and tetrodes, enable us to examine the detailed characteristics of temporal spiking patterns of tens or hundreds of neurons in the hippocampal circuit. Here, we introduce how such tools contribute to our understanding of the hippocampal network dynamics and review several hippocampal functions for information processing in the brain, including pattern separation and completion, spatial representation, and encoding of positive and negative valence.
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