BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 68, Issue 7 (July 2016)

Prevention of Alzheimer's Disease and Nutrients Mieko Otsuka 1 1Department of Neurology, International University of Health and Wellfare Hospital Keyword: アルツハイマー病 , 摂取栄養素 , インスリン抵抗性 , 中鎖脂肪酸 , ケトン体 , Alzheimer's disease , nutrients , insulin resistance , medium-chain triglyceride , ketone body pp.809-817
Published Date 2016/7/1
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The dietary recommendations for the prevention and management of Alzheimer's disease (AD), are the Mediterranean diet and the Japanese-style diet, both of which contain well-balanced nutrients from fish and vegetables. These diets are rich in vitamin E, carotenes, antioxidant flavonoids, vitamin B12, folate, and n-3PUFA. According to recent review supplementation of folate and vitamin E may protect against elderly people's cognitive decline when the serum folate is <12 nmol/L or the vitamin E intake is <6.1 mg/day.

Another nutritional topic with regard to dementia and diet is the association of type-2 diabetes and hyperinsulinemia with AD. Expression array data of the brain tissue of AD patients in the Hisayama study strongly suggests a disturbance in insulin signaling in the AD brain. The dysfunction of insulin signaling could directly lead to disrupted glucose utilization in the AD brain. Instead of improperly utilized glucose, the medium chain triglyceride ketone bodies can be an alternative energy resource for the AD brain.

In conclusion, the dietary recommendations for the prevention and management of AD are a high consumption of fish, vegetables, and low glycemic index fruits; a moderate amount of meat and dairy products; and a lower amount of carbohydrates and refined sugar.

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BRAIN and NERVE-神経研究の進歩
68巻7号 (2016年7月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院