BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 67, Issue 2 (February 2015)

Morphological and Functional Diversity of Retinal Ganglion Cells in the Common Marmoset Amane Koizumi 1 1National Institutes of Natural Sciences Keyword: 網膜 , 視覚情報処理 , 網膜組織培養 , 遺伝子導入 , 多様性 , retina , visual information processing , organotypic culture of retina , gene transfection , diversity pp.193-198
Published Date 2015/2/1
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Retinal ganglion cells are projecting neurons that send visual information from the retina to the brain. They generate different patterns of action potentials in response to different kinds of visual information. In the retinas of mammals such as mice or rabbits, there are functionally and morphologically diverse retinal ganglion cells. However, in the primate retina, midget and parasol cells are believed to be dominant, and show less diversity. In this study, we performed organotypic culture of retinas and acute gene transfection of GFPs by gene-gun. We found more diverse retinal ganglion cells, including directional selective ganglion cells, than we expected, even in the retinas of primates such as common marmosets. Further, we found a third pathway from the retina to the brain via the thalamus, in addition to the magnocellular and parvocellular pathways.

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BRAIN and NERVE-神経研究の進歩
67巻2号 (2015年2月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院