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Japanese

Neurotoxicity of Radiation Keiji Suzuki 1 1Department of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University Keyword: 放射線 , 高次脳機能障害 , DNA損傷 , 神経幹細胞 , アポトーシス , radiation , higher brain function , DNA damage , neural stem cells , apoptosis pp.63-71
Published Date 2015/1/1
DOI https://doi.org/10.11477/mf.1416200087
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Abstract

It is well-known that the central nervous system is thoroughly resistant to ionizing radiation as high-dose radiation exposure is required for causing neuronal death. In contrast, recent studies have revealed that the hippocampus, which could be the main organ involved in disorder of higher brain functions after radiation therapy, contains radiation-sensitive cell fractions. In this paper, the basics of radiation effects and the molecular mechanism of neurotoxicity of radiation have been reviewed and discussed.


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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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